Roundhouse AI

ClinicalIntelPulse

Pharmaceutical pipeline and clinical trial intelligence API. Synthesizes 400,000+ registered trials from ClinicalTrials.gov with FDA OpenFDA, PubMed, and real-time news.

OtherLiveeip155:8453Exactvia cdp
https://clinicalintelpulse.theaslangroupllc.com/api/clinical/failure-analysis
Trial-failureSuccess-ratesEndpoint-selectionPatient-stratificationDrug-development
Calls · 30d
1→ 0%
This endpoint's own trailing-30-day call count, as published by the upstream catalog and snapshotted daily. 27 snapshots so far.
$768.65
Verified settled volume
A floor: summed over 5,000 of 11,309 verified settlements.
$0.200
Listed price
As published in the catalog. Always read the live 402 before paying.
1
Calls · 30d
Upstream's own call count for this endpoint, not ours.
1
Unique payers · 30d
Last called 2026-08-20 14:01Z
—
Upstream on-chain volume
Reported by the source catalog.
Paid to
0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc

The wallet the 402 directs payment to. Its whole payment record — every payer, every chain — is on the merchant page.

Asset 0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913

Provider

The payTo wallet does not resolve to a registered ERC-8004 agent. That is not a verdict on the service — most of the catalog is unregistered.

Live 402 challenge

Captured by the enrichment pass, not read just now. Prices can change — always read the 402 the endpoint answers with.

{
  "error": "X-PAYMENT header is required",
  "accepts": [
    {
      "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
      "extra": {
        "name": "USD Coin",
        "version": "2"
      },
      "payTo": "0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc",
      "scheme": "exact",
      "network": "base",
      "mimeType": "application/json",
      "resource": "https://clinicalintelpulse.theaslangroupllc.com/api/clinical/failure-analysis",
      "description": "Clinical trial failure analysis for a disease area — why Phase 2/3 trials failed (wrong target, patient population, endpoint, dose, safety), failure taxonomy with percentages, phase-transition success rates and design lessons. Worldwide. For drug developers and biotech investors.",
      "maxAmountRequired": "200000",
      "maxTimeoutSeconds": 300
    }
  ],
  "x402Version": 1
}

Accepts

The payment requirements as published to the catalog. Read the live 402 before paying — a price here is a claim, not a quote.

0.2USDC≈ $0.2 USD
on Base · exact scheme

Pay 0.2 USDC on Base to 0x50ab…912fc. The signed payment is good for 5 minutes.

Paid to
0x50ab…912fc
USD Coin contract
0x8335…02913
Payment window
5 minutes
As published
200000 smallest units
0.2USDC≈ $0.2 USD
on Base · exact scheme

Pay 0.2 USDC on Base to 0x50ab…912fc. The signed payment is good for 168 hours.

Paid to
0x50ab…912fc
USD Coin contract
0x8335…02913
Payment window
168 hours
As published
200000 smallest units
200000units
on solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
985iFj…B5KX1
Token contract
EPjFWd…TDt1v
Payment window
5 minutes
200000units
on Polygon · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
0x50ab…912fc
Token contract
0x3c49…c3359
Payment window
5 minutes
200000units
on Arbitrum · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
0x50ab…912fc
Token contract
0xaf88…e5831
Payment window
5 minutes
200000units
on eip155:480 · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
0x50ab…912fc
Token contract
0x79A0…D24D1
Payment window
5 minutes
200000units
on eip155:143 · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
0x50ab…912fc
Token contract
0x7547…fb603
Payment window
5 minutes
200000units
on eip155:196 · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
0x50ab…912fc
Token contract
0x779d…13736
Payment window
5 minutes
200000units
on eip155:999 · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
0x50ab…912fc
Token contract
0xb883…a630f
Payment window
5 minutes
200000units
on algorand:wGHE2Pwdvd7S12BL5FaOP20EGYesN73k · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
62A253…WGI7I
Token contract
31566704
Payment window
5 minutes
200000units
on xrpl:0 · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
rMnHeu…PEh32
Token contract
XRP
Payment window
5 minutes
0.2units
on xrpl:0 · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
rMnHeu…PEh32
Token contract
524C55…00000
Payment window
5 minutes
200000000000000000units
on eip155:56 · exact scheme

That figure is in the token’s smallest units. Roundhouse does not hold this contract’s decimals, so it is shown as published rather than converted.

Paid to
0x50ab…912fc
Token contract
0x8d0D…08B0d
Payment window
5 minutes
The catalog’s raw entry
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    "extra": {
      "name": "USD Coin",
      "version": "2"
    },
    "payTo": "0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc",
    "amount": "200000",
    "scheme": "exact",
    "network": "eip155:8453",
    "maxTimeoutSeconds": 300
  },
  {
    "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
    "extra": {
      "name": "GatewayWalletBatched",
      "version": "1",
      "verifyingContract": "0x77777777dcc4d5a8b6e418fd04d8997ef11000ee"
    },
    "payTo": "0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc",
    "amount": "200000",
    "scheme": "exact",
    "network": "eip155:8453",
    "maxTimeoutSeconds": 604900
  },
  {
    "asset": "EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v",
    "extra": {
      "feePayer": "Hc3sdEAsCGQcpgfivywog9uwtk8gUBUZgsxdME1EJy88"
    },
    "payTo": "985iFjbnGQ3dJcwXnfRCMSrH4Jnc3kW1N6msR64B5KX1",
    "amount": "200000",
    "scheme": "exact",
    "network": "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp",
    "maxTimeoutSeconds": 300
  },
  {
    "asset": "0x3c499c542cEF5E3811e1192ce70d8cC03d5c3359",
    "extra": {
      "name": "USD Coin",
      "version": "2"
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    "payTo": "0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc",
    "amount": "200000",
    "scheme": "exact",
    "network": "eip155:137",
    "maxTimeoutSeconds": 300
  },
  {
    "asset": "0xaf88d065e77c8cC2239327C5EDb3A432268e5831",
    "extra": {
      "name": "USD Coin",
      "version": "2"
    },
    "payTo": "0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc",
    "amount": "200000",
    "scheme": "exact",
    "network": "eip155:42161",
    "maxTimeoutSeconds": 300
  },
  {
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    "extra": {
      "name": "USDC",
      "version": "2"
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    "payTo": "0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc",
    "amount": "200000",
    "scheme": "exact",
    "network": "eip155:480",
    "maxTimeoutSeconds": 300
  },
  {
    "asset": "0x754704Bc059F8C67012fEd69BC8A327a5aafb603",
    "extra": {
      "name": "USDC",
      "version": "2"
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    "payTo": "0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc",
    "amount": "200000",
    "scheme": "exact",
    "network": "eip155:143",
    "maxTimeoutSeconds": 300
  },
  {
    "asset": "0x779ded0c9e1022225f8e0630b35a9b54be713736",
    "extra": {
      "name": "USD₮0",
      "version": "1"
    },
    "payTo": "0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc",
    "amount": "200000",
    "scheme": "exact",
    "network": "eip155:196",
    "maxTimeoutSeconds": 300
  },
  {
    "asset": "0xb88339CB7199b77E23DB6E890353E22632Ba630f",
    "extra": {
      "name": "USDC",
      "version": "2"
    },
    "payTo": "0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc",
    "amount": "200000",
    "scheme": "exact",
    "network": "eip155:999",
    "maxTimeoutSeconds": 300
  },
  {
    "asset": "31566704",
    "extra": {
      "feePayer": "ZMFK2OI7ZBD2U27ISERZC4S6LKM6WMFJPZQ4MYNJDZ2VNBNMBA67RA22AA"
    },
    "payTo": "62A253YPATFNJCPRKID3FKD77MYJFNTVRYRP4B4JWG36EGLPY7UXFWGI7I",
    "amount": "200000",
    "scheme": "exact",
    "network": "algorand:wGHE2Pwdvd7S12BL5FaOP20EGYesN73k",
    "maxTimeoutSeconds": 300
  },
  {
    "asset": "XRP",
    "extra": {
      "invoiceId": "23344652609147ADA57107C98E2E55BF",
      "sourceTag": 804681468
    },
    "payTo": "rMnHeutYALco8RYFVcmuU4BCgSzBpPEh32",
    "amount": "200000",
    "scheme": "exact",
    "network": "xrpl:0",
    "maxTimeoutSeconds": 300
  },
  {
    "asset": "524C555344000000000000000000000000000000",
    "extra": {
      "issuer": "rMxCKbEDwqr76QuheSUMdEGf4B9xJ8m5De",
      "invoiceId": "D906735C80F54D22A27578CA9C9B5613",
      "sourceTag": 804681468
    },
    "payTo": "rMnHeutYALco8RYFVcmuU4BCgSzBpPEh32",
    "amount": "0.2",
    "scheme": "exact",
    "network": "xrpl:0",
    "maxTimeoutSeconds": 300
  },
  {
    "asset": "0x8d0D000Ee44948FC98c9B98A4FA4921476f08B0d",
    "extra": {
      "name": "World Liberty Financial USD",
      "version": "1",
      "signerAddress": "0x34F7a661160780Ce1346e6D7B96D2bE244590899",
      "assetTransferMethod": "eip3009"
    },
    "payTo": "0x50ab2018c06c6E4eAA9BA52057Eb55eD284912fc",
    "amount": "200000000000000000",
    "scheme": "exact",
    "network": "eip155:56",
    "maxTimeoutSeconds": 300
  }
]

Extensions

{
  "bazaar": {
    "info": {
      "input": {
        "type": "http",
        "method": "GET",
        "queryParams": {
          "lang": "en | es | fr | de | ja | zh | ko | pt | ar | hi (default: en)",
          "condition": "Disease — e.g. \"Alzheimer Disease\" | \"Sepsis\" | \"ALS\" | \"Depression\" | \"NASH\""
        }
      },
      "output": {
        "type": "json",
        "example": {
          "query_summary": {
            "condition": "Alzheimer Disease",
            "trials_analyzed": 78
          },
          "lessons_learned": [
            "Early intervention is critical — treat pre-symptomatic or MCI only",
            "Amyloid PET and CSF biomarkers required for enrollment (not just clinical diagnosis)",
            "CDR-SB global score now accepted primary endpoint by FDA (post-2018)",
            "ARIA management protocols must be pre-specified — not post-hoc",
            "Combination approaches (amyloid + tau + neuroinflammation) likely needed"
          ],
          "failure_taxonomy": {
            "wrong_endpoint": {
              "pct": 18,
              "examples": [
                "ADAS-Cog and MMSE insensitive to early disease changes; CDR-SB now standard"
              ],
              "key_trials": [
                "Multiple agents 2010-2020"
              ]
            },
            "safety_termination": {
              "pct": 8,
              "examples": [
                "ARIA (amyloid-related imaging abnormalities) from anti-amyloid antibodies; dose-limiting"
              ],
              "key_trials": [
                "Aducanumab Phase 3 dose arm"
              ]
            },
            "operational_failures": {
              "pct": 4,
              "examples": [
                "COVID-19 disruption, enrollment failures in rare AD subpopulations"
              ]
            },
            "wrong_patient_population": {
              "pct": 28,
              "examples": [
                "Treating symptomatic patients too late — amyloid deposited 10-15 years before symptoms"
              ],
              "key_trials": [
                "Bapineuzumab (mild-moderate vs. early)"
              ]
            },
            "wrong_target_or_hypothesis": {
              "pct": 42,
              "examples": [
                "Decades of amyloid-only focus; tau, neuroinflammation, synaptic loss all contributing to failure cascade"
              ],
              "key_trials": [
                "Solanezumab",
                "Verubecestat",
                "Atabecestat"
              ]
            }
          },
          "what_still_might_fail": [
            "Tau-targeting agents if amyloid clearance alone sufficient",
            "Agents tested in wrong disease stage despite lessons",
            "CNS inflammation approaches without biomarker stratification"
          ],
          "historical_success_rates": {
            "phase2_to_phase3_pct": 31,
            "phase3_to_approval_pct": 11,
            "vs_all_diseases_benchmark": "Alzheimer's has the lowest Phase 3 success rate of any major disease category (11% vs. 58% oncology, 67% hematology)",
            "overall_clinical_success_pct": 3.4
          },
          "successful_design_principles": "CLARITY-AD (lecanemab) and TRAILBLAZER-ALZ2 (donanemab) succeeded by: earlier disease staging, biomarker-confirmed enrollment, CDR-SB endpoint, adequate duration."
        }
      }
    },
    "schema": {
      "type": "object",
      "$schema": "https://json-schema.org/draft/2020-12/schema",
      "required": [
        "input"
      ],
      "properties": {
        "input": {
          "type": "object",
          "required": [
            "type",
            "method"
          ],
          "properties": {
            "type": {
              "type": "string",
              "const": "http"
            },
            "method": {
              "enum": [
                "GET",
                "HEAD",
                "DELETE"
              ],
              "type": "string"
            },
            "queryParams": {
              "type": "object",
              "properties": {
                "lang": {
                  "type": "string"
                },
                "condition": {
                  "type": "string"
                }
              }
            }
          },
          "additionalProperties": false
        },
        "output": {
          "type": "object",
          "required": [
            "type"
          ],
          "properties": {
            "type": {
              "type": "string"
            },
            "example": {
              "type": "object"
            }
          }
        }
      }
    }
  },
  "builder-code": {
    "info": {
      "a": "bc_gxy6qn5p"
    },
    "schema": {
      "type": "object",
      "$schema": "https://json-schema.org/draft/2020-12/schema",
      "properties": {
        "a": {
          "type": "string",
          "pattern": "^[a-z0-9_]{1,32}$",
          "description": "App builder code"
        },
        "s": {
          "type": "array",
          "items": {
            "type": "string",
            "pattern": "^[a-z0-9_]{1,32}$"
          },
          "description": "Service builder codes"
        },
        "w": {
          "type": "string",
          "pattern": "^[a-z0-9_]{1,32}$",
          "description": "Wallet builder code"
        }
      },
      "additionalProperties": false
    }
  }
}

Provenance

Seen in the source catalog
2026-08-20 14:01Z
Last indexed by Roundhouse
2026-09-19 13:40Z
Last enriched (probe, favicon, geo)
2026-09-20 03:15Z
x402 version
2
Max timeout
300s
Liveness probe
HTTP 402
Report

Hand this page to an agent

Copy the prompt and paste it into Claude, an MCP client or your own agent — it will vet this service and call it over the free read API. No key, no account.

GET api.roundhouseai.io/v0/endpoints

This endpoint's own trailing-30-day call count, as published by the upstream catalog and snapshotted daily. 27 snapshots so far. Verified volume counts only settlements with an on-chain EIP-3009 marker.

Open skill.md
Show the prompt
Using Roundhouse, look up the x402 service ClinicalIntelPulse and tell me whether it is
worth paying: what a call costs, whether the endpoint answered when last probed, and what
its payment record actually shows.

curl -s 'https://api.roundhouseai.io/v0/endpoints?q=ClinicalIntelPulse'
curl -s 'https://api.roundhouseai.io/v0/merchants/<the payTo wallet returned above>'

Then call it: read the price from the live 402 at https://clinicalintelpulse.theaslangroupllc.com/api/clinical/failure-analysis, never from
a cached figure, and pay with an x402 client.

The /v0 API needs an API key (`authorization: Bearer rh_live_…`) on everything except
/v0/unified* and /v0/endpoints. Mint a personal key for $0.01 at GET https://api.roundhouseai.io/v0/test/x402,
or use an organization key from https://roundhouseai.io/dashboard/team.

If you do not have Roundhouse tools or skills installed, read
https://roundhouseai.io/skill.md first — it is the whole procedure.